Differential Utilization of Saturated Palmitate and Unsaturated Oleate: Evidence From Cultured Myotubes
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چکیده
منابع مشابه
Differential utilization of saturated palmitate and unsaturated oleate: evidence from cultured myotubes.
We recently described a primarily reduced palmitate oxidation in myotubes established from type 2 diabetic subjects, whereas triacylglycerol (TAG) accumulation seemed to be adaptive. However, it is still uncertain whether these changes are similar for saturated and unsaturated fatty acids and whether high concentrations of glucose and/or insulin may change this picture. Studies of palmitic acid...
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Oleate has been shown to protect against palmitate-induced insulin resistance. The present study investigates mechanisms involved in the interaction between oleate and palmitate on insulin-stimulated glucose uptake by L6 skeletal muscle cells. L6 myotubes were cultured for 6 h with palmitate or oleate alone, and combinations of palmitate with oleate, with and without phosphatidylinositol 3-kina...
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Accumulation of saturated fatty acids contributes to lipotoxicity-related insulin resistance and atrophy in skeletal muscle. Conversely, unsaturated fatty acids like docosahexaenoic acid were proven to preserve muscle mass. However, it is not known if the most common unsaturated oleate will protect skeletal myotubes against palmitate-mediated atrophy, and its specific mechanism remains to be el...
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Saturated fatty acids are implicated in the development of insulin resistance, whereas unsaturated fatty acids may have a protective effect on metabolism. We tested in primary human myotubes if insulin resistance induced by saturated fatty acid palmitate can be ameliorated by concomitant exposure to unsaturated fatty acid oleate. Primary human myotubes were pretreated with palmitate, oleate or ...
متن کاملThe biosynthesis of unsaturated fatty acids by bacilli. 3. Uptake and utilization of exogenous palmitate.
The apparent in viva substrate specificities for six bacilli desaturases, previously shown to insert a c&double bond into position five of palmitate and of one which desaturates in position 10 were determined in whole cells by a variety of methods. In addition, the positional specificity of double bond insertion and the rate of temperature-mediated inactivation of these desaturases were also de...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2005
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diabetes.54.3.648